| Autor: |
Zhi, Guo, Hui-Ren, Chen, Xiao-Dong, Liu, Jia-Ming, Bian, Xue-Peng, He, Jin-Xing, Lou, Peng, Chen, Kai, Yang, Dan, Liu, Yuan, Zhang |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Zhongguo shi yan xue ye xue za zhi. 20(4) |
| ISSN: |
1009-2137 |
| Popis: |
The objective of this study was to explore the incidence and therapeutic efficacy of cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical data of 140 patients undergoing allo-HSCT in our department of hematology from 2010-01 to 2012-01 were retrospectively analyzed. The results showed that the incidence of CMV infection was 4.3% (48/140), the time for the first detection of positive CMV-DNA was at day 45 (33 to 68) after allo-HSCT, and the CMV quantitative range was 1.25×10(3) - 5.5×10(6). There were 2 cases of CMV-related interstitial pneumonia and 5 cases of hemorrhagic bladder inflammation. A total of 65 patients suffered from graft versus host disease (GVHD), in which 32 cases (49.2%) were accompanied with CMV infection, CMV-DNA negative in patients treated with ganciclovir, foscarnet sodium anti-CMV was at day 45 (33 to 68) with the effective rate of 100%. 12 patients with CMV infection were accompanied with transient neutropenia and thrombocytopenia. It is concluded that after allo-HSCT the CMV infection occurs frequently. The patients with GVHD have a higher incidence of CMV infection. Ganciclovir and foscarnet sodium are reliable to be used for treatment of CMV infection with fewer adverse reactions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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