| Autor: |
Yasmim A, Serra, Thaísa, Barros-Santos, Alexia, Anjos-Santos, Natali D, Kisaki, Caio, Jovita-Farias, João P C, Leite, Maria C E, Santana, João P S A, Coimbra, Nailton M S, de Jesus, Agnieszka, Sulima, Paulo C R, Barbosa, Elena L A, Malpezzi-Marinho, Kenner C, Rice, Alexandre J, Oliveira-Lima, Laís F, Berro, Eduardo A V, Marinho |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Psychopharmacology. 239(6) |
| ISSN: |
1432-2072 |
| Popis: |
Ayahuasca has been proposed as a potential treatment of alcohol (ethanol) use disorder (AUD). The serotonin 5-HTThe aim of the present study was to investigate the effects of ayahuasca on the expression of ethanol self-administration using a two-bottle choice procedure and the role of 5-HTMale mice had intermittent access to ethanol (10% v/v) in a two-bottle choice procedure for 30 days. Animals were then submitted to 3 treatment phases, each followed by ethanol re-exposure tests. During the treatment phase, every 3 days, animals received i.p. injections of either vehicle or the 5-HTTreatment with ayahuasca blocked the expression of ethanol self-administration, decreasing ethanol intake and preference during re-exposure tests. Pretreatment with M100 blocked the effects of ayahuasca on ethanol drinking without significantly attenuating ethanol self-administration.Treatment with ayahuasca during alcohol abstinence blocked the expression of alcohol self-administration in mice, and 5-HT |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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