Pre-B-cell acute lymphoblastic leukemia with bulk extramedullary disease and chromosome 22 (EWSR1) rearrangement masquerading as Ewing sarcoma
| Autor: | Gordana, Jakovljević, Melita, Nakić, Srdan, Rogosić, Ika, Kardum-Skelin, Sanja, Mrsić-Davidović, Renata, Zadro, Bozo, Kruslin |
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| Rok vydání: | 2010 |
| Předmět: |
Oncogene Proteins
Fusion Proto-Oncogene Protein c-fli-1 Reverse Transcriptase Polymerase Chain Reaction Chromosomes Human Pair 22 Soft Tissue Neoplasms Sarcoma Ewing Immunohistochemistry Diagnosis Differential Child Preschool Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Antineoplastic Combined Chemotherapy Protocols Humans Female RNA-Binding Protein EWS In Situ Hybridization Fluorescence Transcription Factors |
| Zdroj: | Pediatric bloodcancer. 54(4) |
| ISSN: | 1545-5017 |
| Popis: | We report a 2-year-old female with a subcutaneous tumor who was initially misdiagnosed as suffering from Ewing sarcoma with a positive EWSR1 rearrangement and EWS/FLI1 transcript. After finding lymphoblasts in peripheral blood, the diagnosis of acute lymphoblastic leukemia was established. This necessitated further analysis of the subcutaneous tumor. The tissue was positive for immature B-cell markers and an immunoglobulin heavy chain gene rearrangement, which confirmed the final diagnosis of common type acute lymphoblastic leukemia with bulk extramedullary disease. The patient was treated with chemotherapy and was in remission 30 months after the diagnosis. |
| Databáze: | OpenAIRE |
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