[Primary resistance of Mycobacterium tuberculosis to anti-tuberculosis drugs in Kinshasa, (DRC)]
| Autor: | M J, Kabedi, M, Kashongwe, J M, Kayembe, D, Mumba Ngoyi, P, Mampasi, P, Mbaya, K, Fissette, J, Verhaegen, F, Portaels, J J, Muyembe-Tamfum |
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| Jazyk: | francouzština |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Adolescent Antitubercular Agents Mycobacterium Infections Nontuberculous Nontuberculous Mycobacteria Mycobacterium tuberculosis Middle Aged Cross-Sectional Studies Tuberculosis Multidrug-Resistant Democratic Republic of the Congo Isoniazid Prevalence Streptomycin Humans Female Rifampin Child Tuberculosis Pulmonary Ethambutol Aged |
| Zdroj: | Bulletin de la Societe de pathologie exotique (1990). 100(4) |
| ISSN: | 0037-9085 |
| Popis: | In a descriptive cross-sectional study carried out in Kinshasa between July 2003 and January 2004, we determined the prevalence of the primary resistance of M. tuberculosis to first-line anti-tuberculosis drugs. The antibiogram was performed with the proportion method on 301 isolats from patients who all had a first episode of pulmonary tuberculosis with positive microscopy (TPM+) and who had not received any anti-tuberculosis treatment before. The primary resistance rate reached 43.5%; it reached 31.6% in 1990. The multi-drug-resistance rate (MDR-TB) notified as resistant to both rifamicine and isoniazide rose to 5.3%. This rate of primary resistance is among the highest in Africa. The emergence of the resistant strains and specially the multi-drug-resistant strains (MDR-TB) in Kinshasa requires a regular assessment of these phenomena which threaten seriously the implementation of the national tuberculosis control programme. |
| Databáze: | OpenAIRE |
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