HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis)

Autor:	F K, Tan, D N, Stivers, F C, Arnett, R, Chakraborty, R, Howard, J D, Reveille
Rok vydání:	1999
Předmět:	Scleroderma Systemic Genotype Oklahoma Polymerase Chain Reaction Linkage Disequilibrium Autoimmune Diseases Pedigree Major Histocompatibility Complex Haplotypes HLA Antigens Indians North American Prevalence Humans Genetic Predisposition to Disease Microsatellite Repeats
Zdroj:	Tissue antigens. 53(1)
ISSN:	0001-2815
Popis:	Choctaw Native Americans in southeastern Oklahoma have the highest prevalence of scleroderma or systemic sclerosis yet found (469/100,000). An Amerindian HLA DR2 haplotype (DRB1*1602) was significantly associated with scleroderma in this population in a previous study. It is not known, however, if other disease genes are linked to this HLA haplotype. The regions flanking the HLA loci were studied with polymorphic microsatellite markers. An extended HLA DR2 (DRB1*1602, DQA1*0501, DQB1*0301, DPB1*1301) haplotype that includes the class I and III regions was identified which was significantly associated with scleroderma in the Oklahoma Choctaw. No other significant associations with microsatellite marker alleles immediately flanking the HLA region were found.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f2cbcdaaba1457e871ca7ffffae9d285 https://pubmed.ncbi.nlm.nih.gov/10082433 Zobrazit plný text záznamu Plný text ve formátu PDF