| Autor: |
M C, Delmas, C, Larsen, B, van Benthem, F F, Hamers, C, Bergeron, J D, Poveda, B, Anzén, A, van den Hoek, F, Meier, J M, Peña, H, Savonius, D, Sperandeo, B, Suligoi, P, Vernazza, J B, Brunet |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
AIDS (London, England). 14(12) |
| ISSN: |
0269-9370 |
| Popis: |
To assess the impact of HIV-related immunodeficiency and antiretroviral treatment on the occurrence and evolution of abnormal Papanicolaou tests.Cohort of 485 HIV-infected women with a known date of infection, enrolled during May 1993-April 1998 in 23 centres (gynaecology, infectious disease or STD clinics, or drug treatment centres) in 12 European countries; in 21 centres, follow-up was performed every 6 months (median follow-up: 2 years).Human papillomavirus (HPV) was detected at inclusion by Southern blot and PCR. The prevalence of squamous intraepithelial lesions (SIL), the incidence of SIL and regression from low-grade SIL were studied according to CD4 count after controlling for HPV detection results.Compared with women with CD4 cell counts500 x 10(6)/l, women with CD4 cell counts200 x 10(6)/l had a twofold increase in both prevalence and incidence of SIL and in non-regression from untreated low-grade SIL; in addition, these women had a lower response rate to treatment of high-grade cervical intraepithelial neoplasia. The increase in SIL incidence associated with a low CD4 cell count was significant in women not receiving antiretroviral treatment (relative risk, CD4 cell count 200-499 x 10(6)/l, 1.9; CD4 cell count200 x 10(6)/l, 2.9; CD4 cell count500 x 10(6)/l, reference), whereas it was less marked and not statistically significant in treated women.Severe HIV-related immunodeficiency strongly increases the risk of occurrence of SIL; antiretroviral treatment may reduce this risk, probably by restoring or at least preserving immune function. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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