[Activity of the xenobiotic metabolism system under the effect of chemical pollution of the atmosphere and water]

Autor:	L Kh, Mukhambetova, A A, Nasonova, S I, Dolinskaia
Rok vydání:	1993
Předmět:	Male Air Pollutants Aniline Compounds Hydroxylation Methylation Rats Xenobiotics Kinetics Cytochromes b5 Cytochrome P-450 Enzyme System Microsomes Liver Animals Glucuronosyltransferase Aminopyrine Water Pollutants Chemical
Zdroj:	Voprosy meditsinskoi khimii. 39(6)
ISSN:	0042-8809
Popis:	Functional state of the system involved in biotransformation of xenobiotics in animal liver tissue was studied under conditions of combined chemical contamination of atmospheric air and water simulating the typical real loading. The model loading studied caused in some cases an induction of the microsomal monooxygenases without activation of UDP-glucuronosyl transferase, but simultaneously with accumulation of malonic dialdehyde; this suggests that metabolic alterations observed may be involved in development of pathology.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f28919fe5e6b19771c8dde64d1cf08bf https://pubmed.ncbi.nlm.nih.gov/8303878 Zobrazit plný text záznamu