| Autor: |
H, Allain, S, Belliard, A, Lieury, G, Menard, A, Patat, F, Le Coz, J M, Gandon |
| Jazyk: |
francouzština |
| Rok vydání: |
1996 |
| Předmět: |
|
| Zdroj: |
Therapie. 51(2) |
| ISSN: |
0040-5957 |
| Popis: |
Thirty five subjects (age: 45-69 years) with subjective memory loss, without any other neuropsychiatric or somatic disease, were recruited in a phase II study. This double blind randomized versus placebo controlled study compared the effects of minaprine (200 mg/d) with placebo, in two parallel groups, during 2 months, on memory, attention and vigilance. Three psychometric tests were the main criteria of assessment: a standardized battery of memory tests (SM 5), the dual-coding test, the analysis of choice reaction times (CRT) and the critical flicker fusion point (CFF). A positive effect of minaprine was detected on words delayed recall (p = 0.028) and immediate recognition of words (p = 0.049). The global clinical tests (CGI, MacNair scale) were not statistically modified. Tolerability of minaprine and placebo were comparable. A positive pharmacodynamic activity on mnemonic performance is thus demonstrated in favour of minaprine (200 mg/d) in this specific population characterized by a memory complaint. These results would lead to a phase III study in which the main criteria would be global scales in order to confirm the clinical reliability of the present results. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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