Novel monoacetoneglucose derivatives with calcium antagonist activity

Autor: T, Bécaert, P, Vanlemmens, P, Villa, A, Lahyani, J, Lehouelleur, D, Postel, G, Ronco, G, Brulé
Rok vydání: 1996
Předmět:
Zdroj: Bollettino chimico farmaceutico. 135(3)
ISSN: 0006-6648
Popis: Ethers and thioethers of monosaccharides have been synthesised which show potent toxicity to mouse (LD50or = 4 g.kg-1 O.W. and 0.2 to 1.5 g.kg-1 I.P.W.). A study of calcium antagonist activity for the full series of compounds indicated that the activity was similar for both O- and S- ethers and maximum activities were observed for monoacetoneglucose ethers possessing carbon chain close to 8 carbons.
Databáze: OpenAIRE