| Autor: |
Theodoros P, Vassilakopoulos, Maria K, Angelopoulou, Marina P, Siakantaris, Flora N, Kontopidou, Maria N, Dimopoulou, Dimitrios E, Boutsis, Konstantinos, Anargyrou, Styliani I, Kokoris, Antonia, Giannakakis, Christos, Karkantaris, Marie-Christine, Kyrtsonis, Panayiotis, Tsaftaridis, John, Rombos, Eleni, Variamis, Pinelopi, Korkolopoulou, Christos, Kittas, Gerassimos A, Pangalis |
| Rok vydání: |
2002 |
| Předmět: |
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| Zdroj: |
European journal of haematology. 68(5) |
| ISSN: |
0902-4441 |
| Popis: |
To investigate the prognosis of patients with Hodgkin's lymphoma (HL) who relapse following a complete remission (CR) achieved by chemotherapy with or without radiotherapy (CT+/-RT), and to identify prognostic factors for freedom from second progression (FF2P).We analyzed the prognostic significance of the initial CT regimen (4 vs. 7-8 drugs), treatment-free interval (TFI), and demographic, clinical, and laboratory factors at the time of relapse and diagnosis, in 113 patients with HL, who relapsed after a CR achieved by CT+/-RT.Conventional salvage CT+/-RT was administered in 107 patients, while six received RT only. The 5-yr FF2P was 24%, while the 10-yr survival after relapse (O2S) was 39% and was not afffected by the initial CT regimen. Multivariate analysis revealed that extranodal disease at relapse (P0.001), TFI6 month (P0.001),or =5 involved sites at diagnosis (P=0.04) and anemia at relapse (P=0.03) were independent predictors of FF2P. 55% of patients had 0 or 1 of these adverse prognostic factors. The 5-yr FF2P of patients with 0, 1 or 2 adverse factors was 58%, 34% and 5% (P0.0001). The corresponding rates for 10-yr O2S were 68%, 51% and 25%, respectively (P=0.002).Our data confirmed the significance of TFI and extranodal relapse and demonstrated a potential role for anemia at relapse and number of involved sites at diagnosis, for the prognosis of patients with HL relapsing after CT+/-RT. The combination of these prognostic factors defines a sizeable subgroup of patients with favorable outcome following conventional salvage therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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