| Autor: |
H, Escobar Castro, M, Perdomo Giraldi, A, Tamáriz-Martel Moreno, L, Suárez Cortina |
| Rok vydání: |
1988 |
| Předmět: |
|
| Zdroj: |
Anales espanoles de pediatria. 28(6) |
| ISSN: |
0302-4342 |
| Popis: |
A randomized, double-blind trial was performed to assess serological response and clinical protection for acute gastroenteritis due to rotavirus in 103 children aged 6 to 18 months, after a single dose of RIT 4237 live attenuated bovine rotavirus vaccine or placebo. Seroconversion, determined by enzyme-linked immunoabsorbent assay (ELISA), was significantly greater in initially seronegative vaccines compared with control group (p less than 0.0001); clinical protection rate was low in this study group and it is therefore concluded that seroconversion by itself is not sufficient to measure vaccine efficacy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
