[The effect of reaferon on the opioid systems of chronically alcoholized rats]

Autor:	O B, Petrichenko, A M, Balashov, T N, Aliab'eva, L F, Panchenko
Rok vydání:	1995
Předmět:	Brain Chemistry Male Enkephalin Methionine beta-Endorphin Drug Evaluation Preclinical Brain Interferon-alpha Interferon alpha-2 Ligands Recombinant Proteins Rats Alcoholism Radioligand Assay Interferon Type I Receptors Opioid Animals Alcohol Deterrents Protein Binding
Zdroj:	Eksperimental'naia i klinicheskaia farmakologiia. 58(2)
ISSN:	0869-2092
Popis:	Chronic alcoholic intoxication is followed by a fall in 3H-(D-ala-2,D-leu-5)-enkephalin affinity of mu-opioid receptors with their unchanged concentrations in the rat brain cortex, by reductions in the tissue and plasma levels of beta-endorphine and met-enkephalin. A daily administration of reaferon in a dose of 10,000 IU during two fortnights completely restored both the binding affinity of the receptors and the concentrations of the peptides tested: those of beta-endorphine in the adenohypophysis and plasma and those of metenkephalin in the adrenals and plasma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f1df85ab0e1697f366f1c343ee5d326a https://pubmed.ncbi.nlm.nih.gov/7773093 Zobrazit plný text záznamu