Nitric Oxide Induction in Peritoneal Macrophages by a 1,2,3-Triazole Derivative Improves Its Efficacy upon

Autor:	Fernando, Almeida-Souza, Verônica Diniz, da Silva, Noemi Nosomi, Taniwaki, Daiana de Jesus, Hardoim, Ailésio Rocha, Mendonça Filho, Wendel Fragoso de Freitas, Moreira, Camilla Djenne, Buarque, Kátia da Silva, Calabrese, Ana Lucia, Abreu-Silva
Rok vydání:	2021
Předmět:	Leishmania Mice Inbred BALB C Molecular Structure Cell Survival Antiprotozoal Agents Nitric Oxide Synthase Type II Fibroblasts Triazoles Nitric Oxide Gene Expression Regulation Enzymologic Cell Line Mice Macrophages Peritoneal Animals Humans Female
Zdroj:	Journal of medicinal chemistry. 64(17)
ISSN:	1520-4804
Popis:	1,2,3-Triazole is one of the most flexible chemical scaffolds broadly used in various fields. Here, we report the antileishmanial activity of 1,2,3-triazole derivatives, the ultrastructural alterations induced by their treatment, and the nitric oxide (NO) modulation effect on their efficacy against
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f1a89f0547b8db53f9758826ba4dcb5b https://pubmed.ncbi.nlm.nih.gov/34427442 Zobrazit plný text záznamu