Comparison of patients with60% toor = 60% diameter narrowing of the myocardial infarct-related artery after thrombolysis. The TIMI Investigators
| Autor: | M J, Schweiger, R P, McMahon, M L, Terrin, N A, Ruocco, M N, Porway, A H, Wiseman, G L, Knatterud, E, Braunwald |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Cardiac Catheterization Angioplasty Myocardial Infarction Pilot Projects Constriction Pathologic Coronary Angiography Coronary Vessels Survival Rate Treatment Outcome Coronary Circulation Humans Female Thrombolytic Therapy Coronary Artery Bypass Vascular Patency Aged Follow-Up Studies Retrospective Studies |
| Zdroj: | The American journal of cardiology. 74(2) |
| ISSN: | 0002-9149 |
| Popis: | The purpose of this study was to analyze angiographic findings, clinical course, and follow-up data on 1,752 patients who underwent protocol cardiac catheterization 18 to 48 hours after enrollment in the Thrombolysis in Myocardial Infarction (TIMI) II pilot and randomized trial: 244 patients (14.0%) had60% diameter stenosis in the infarct-related artery and TIMI grade 2 or 3 flow, 1,249 (71.2%) had a narrowingor = 60% in diameter with TIMI grade 2 or 3 flow, and 259 patients (15%) had TIMI grade 0 or 1 flow (total occlusion). Patients with60% narrowing in the infarct-related artery were younger (p0.001) and more likely to be current smokers than those with more severe narrowings (p0.003). Patients with60% diameter stenosis in the infarct-related artery were more likely to have a predischarge radionuclide ejection fraction55% (p0.001) than were other patient groups. The 1-year mortality rate of patients with60% diameter stenosis in the infarct-related artery was 1.6% compared with 4.4% for patients with stenosisor = 60% and TIMI grade 2 or 3 flow (p = 0.05) and 7.0% for patients with total occlusion (p = 0.004). Patients with stenosis60% in the infarct-related artery 18 to 48 hours after thrombolytic therapy have a good prognosis. Infarct artery status predicts predischarge ejection fraction and 1-year mortality. |
| Databáze: | OpenAIRE |
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