| Autor: |
Renata G Borges de Oliveira Nascimento, Freitas, Ana Carolina J, Vasques, Gabriel da Rocha, Fernandes, Francieli B, Ribeiro, Isabela, Solar, Marina G, Barbosa, Bianca de Almeida-, Pititto, Bruno, Geloneze, Sandra Roberta G, Ferreira |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Frontiers in cellular and infection microbiology. 12 |
| ISSN: |
2235-2988 |
| Popis: |
Early-life events are associated with the risk of obesity and comorbidities later in life. The gut microbiota-whose composition is influenced by genetics and environmental factors-could be involved. Since the microbiota affects metabolism and fat storage, early-life insults could contribute to the occurrence of obesity driven, in part, by microbiota composition. We examined associations of gut bacteria with early-life events, nutritional status, and body composition in the Nutritionist's Health Study (NutriHS).A cross-sectional study of 114 female participants examining early-life data, body composition, and biological samples was conducted. Fecal microbiota structure was determined targeting the V4 region of the 16S rRNA gene. Principal coordinates analysis (PCoA) and permutational multivariate analysis of variance (PERMANOVA) were used to test the impact of variables on microbial diversity. Profiles were identified using the Jensen-Shannon divergence matrix and Calinski-Harabasz index. Differential abundance between the categories of exclusive breastfeeding duration and nutritional status was tested using DESeq2.In the sample [median age 28 years and body mass index (BMI) 24.5 kg/mFindings in a |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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