| Autor: |
Shang-Fan, Yu, Donna W, Lee, Bing, Zheng, Geoffrey, Del Rosario, Douglas, Leipold, Helen, Booler, Fiona, Zhong, Montserrat, Carrasco-Triguero, Kyu, Hong, Peter, Yan, Rebecca K, Rowntree, Melissa M, Schutten, Thomas, Pillow, Jack D, Sadowsky, Peter S, Dragovich, Andrew G, Polson |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Molecular cancer therapeutics. 20(2) |
| ISSN: |
1538-8514 |
| Popis: |
We are interested in developing a second generation of antibody-drug conjugates (ADCs) for the treatment of non-Hodgkin lymphoma (NHL) that could provide a longer duration of response and be more effective in indolent NHL than the microtubule-inhibiting ADCs pinatuzumab vedotin [anti-CD22-vc-monomethyl auristatin E (MMAE)] and polatuzumab vedotin (anti-CD79b-vc-MMAE). Pinatuzumab vedotin (anti-CD22-vc-MMAE) and polatuzumab vedotin (anti-CD79b-vc-MMAE) are ADCs that contain the microtubule inhibitor MMAE. Clinical trial data suggest that these ADCs have promising efficacy for the treatment of NHL; however, some patients do not respond or become resistant to the ADCs. We tested an anti-CD22 ADC with a |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
