Insulin-like growth factors II exon 9 and E-cadherin-Pml I but not myeloperoxidase promoter-463, urokinase-ApaL I nor xeroderma pigmentosum polymorphisms are associated with higher susceptibility to leiomyoma
| Autor: | Yao-Yuan, Hsieh, Chi-Chen, Chang, Yu-Kuo, Wang, Kung-Hao, Hsu, Chih-Ping, Chen, Chin-Mu, Hsu, Fuu-Jen, Tsai |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Leiomyoma Exons Cadherins Polymorphism Single Nucleotide Urokinase-Type Plasminogen Activator Xeroderma Pigmentosum Group A Protein Insulin-Like Growth Factor II Uterine Neoplasms Humans Female Genetic Predisposition to Disease Promoter Regions Genetic Peroxidase Xeroderma Pigmentosum Group D Protein |
| Zdroj: | Anticancer research. 30(6) |
| ISSN: | 1791-7530 |
| Popis: | To investigate the roles of insulin-like growth factor II (IGF2), myeloperoxidase (MPO), E-cadherin (CDH1), urokinase and xeroderma pigmentosum group A and D (XPA, XPD) polymorphisms upon leiomyoma susceptibility.Women were divided into: group 1, leiomyoma (n=158); group 2, non-leiomyoma (n=156). Polymorphisms (IGF2 exon 9*A/G, MPO-463*A/G, CDH1-Pml I, urokinase-ApaL, XPA*A-23G, XPD*Lys751Gln) were amplified by polymerase chain reaction and detected by electrophoresis after restriction enzyme digestion. Genotype and allelic frequencies were compared between both groups.Associations between leiomyoma with IGF2 and CDH1 polymorphism exist. Proportions of IGF2 exon 9*AA/AG/GG in and CDH1* CC/CT/TT in the groups were: group 1, 38/39.2/22.8% and 27.8/66.5/5.7%; group 2, 22.4/53.9/23.7% and 21.2/64.1/14.7. MPO, urokinase, XPA and XPD in both groups were non-significantly different. Proportions of MPO*AA/AG/GG, urokinase*CC/CT/TT, XPA*AA/AG/GG and XPD*AA/AC/CC were: group 1: 1.9/23.4/74.7%, 0.6/7/92.4%, 20.9/55.1/24%, 85.4/14.6/0%; group 2: 3.8/24.4/71.8%, 1.3/4.5/94.2%, 22.4/53.9/23.7%, 84.6/15.4/0%.IGF2*A allele and CDH1*C allele were correlated with leiomyoma susceptibility, which may be associated with leiomyoma development. MPO, urokinase, XPA and XPD polymorphisms are not related to leiomyoma susceptibilities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|