| Autor: |
S, Rossi, T, Schroeder, K, Muth, D, Hanto, R, Munda, S, Hariharan, M R, First, F, Ryckman, W, Balistreri |
| Rok vydání: |
1996 |
| Předmět: |
|
| Zdroj: |
Clinical transplantation. 10(1 Pt 1) |
| ISSN: |
0902-0063 |
| Popis: |
Serial sIL-2R serum levels were evaluated as an indicator of cytomegalovirus infection and response to antiviral therapy. All cases of post-transplant CMV infection or disease were studied over a 2.5-year period with serial sIL-2R serum levels monitored daily post-transplant until discharge, during each inpatient admission and with each outpatient laboratory analysis. Mean sIL-2 levels +/- S.E.M. rose from a baseline level of 3662 +/- 321 U/ml to 11657 +/- 3311 U/ml at the time of diagnosis. Serum sIL-2R concentrations were significantly elevated from baseline as early as 14 days prior to diagnosis of CMV. Mean peak sIL-2R levels occurred an average of 4 days after the initiation of ganciclovir therapy and remained significantly elevated for an average of 20 days of treatment. Serum sIL-2R levels in patients with resolved CMV returned to within 20% of baseline after 20 days of therapy. These data support the idea that serial monitoring of sIL-2R serum levels may be useful adjunctively in the diagnosis of CMV as well as determining the response to and duration of antiviral therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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