| Autor: |
Nicolas, De Leiris, Berangère, Ruel, Jean, Vervandier, José, Boucraut, Stephan, Grimaldi, Tatiana, Horowitz, Jean, Pelletier, Frederique, Fluchere, Jacques-Yves, Campion, Elsa, Kaphan, Eric, Guedj |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
European journal of nuclear medicine and molecular imaging. 49(3) |
| ISSN: |
1619-7089 |
| Popis: |
The aim of this [We retrospectively collected clinical and paraclinical data of patients with AE, including brainFifty-six patients with AE were included. In comparison to healthy subjects, voxel-based statistical analysis identified one large cluster (p-cluster 0.05, FWE corrected) of widespread decreased cortex/striatum ratio in patients with AE. The mean metabolic ratio was significantly lower for AE patients (1.16 ± 0.13) than that for healthy subjects (1.39 ± 0.08; p 0.001) and than that for MCI patients (1.32 ± 0.11; p 0.001). A ratio threshold of 1.23 allowed to detect AE patients with a sensitivity of 71% and a specificity of 82% against MCI patients, and 98% against healthy subjects. A lower cortex/striatum metabolic ratio had a trend towards shorter delay beforeThe decrease in the cortex/striatal metabolic ratio has a good early diagnostic performance for the differentiation of AE patients from controls. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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