The clinical and metabolic effects of rapid weight loss in obese pet cats and the influence of supplemental oral L-carnitine
| Autor: | S A, Center, J, Harte, D, Watrous, A, Reynolds, T D, Watson, P J, Markwell, D S, Millington, P A, Wood, A E, Yeager, H N, Erb |
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| Rok vydání: | 2000 |
| Předmět: |
Male
3-Hydroxybutyric Acid Diet Reducing Biological Availability Spectrometry Mass Fast Atom Bombardment Cat Diseases Animal Feed Statistics Nonparametric Eating Double-Blind Method Liver Animals Domestic Carnitine Abdomen Dietary Supplements Weight Loss Cats Animals Female Obesity Amino Acids Blood Chemical Analysis Ultrasonography |
| Zdroj: | Journal of veterinary internal medicine. 14(6) |
| ISSN: | 0891-6640 |
| Popis: | The efficacy, safety, and metabolic consequences of rapid weight loss in privately owned obese cats by means of a canned weight-reduction diet and the influence of orally administered L-carnitine on rate of weight loss, routine clinical evaluations, hepatic ultrasonography, plasma amino acid profiles, and carnitine analytes were evaluated. A double-blinded placebo-controlled design was used with cats randomly divided into 2 groups: Group 1 (n = 14) received L-carnitine (250 mg PO q24h) in aqueous solution and group 2 (n = 10) received an identical-appearing water placebo. Median obesity (body condition scores and percentage ideal body weight) in each group was 25%. Caloric intake was restricted to 60% of maintenance energy requirements (60 kcal/kg) for targeted ideal weight. The reducing formula was readily accepted by all cats. Significant weight loss was achieved by week 18 in each group without adverse effects (group 1 = 23.7%, group 2 = 19.6%). Cats receiving carnitine lost weight at a significantly faster rate (P.05). Significant increases in carnitine values developed in each group (P.02). However, significantly higher concentrations of all carnitine moieties and a greater percentage of acetylcarnitine developed in cats of group 1 (P.01). The dietary formula and described reducing strategy can safely achieve a 20% weight reduction within 18 weeks in obese cats. An aqueous solution of L-carnitine (250 mg PO q12h) was at least partially absorbed, was nontoxic, and significantly increased plasma carnitine analyte concentrations as well as rate of weight loss. |
| Databáze: | OpenAIRE |
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