Functional vascular endothelial growth factor -634GC SNP is associated with proliferative diabetic retinopathy: a case-control study in a Brazilian population of European ancestry
| Autor: | Flavia I V, Errera, Luís Henrique, Canani, Maria Elisabeth R, Silva, Erika, Yeh, Walter, Takahashi, Katia G, Santos, Katia E P, Souto, Balduíno, Tschiedel, Israel, Roisenberg, Jorge Luis, Gross, Maria Rita, Passos-Bueno |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A Diabetic Retinopathy Blood Pressure Middle Aged Lipids Polymorphism Single Nucleotide White People Body Mass Index Cohort Studies Diabetes Mellitus Type 2 Risk Factors Case-Control Studies Surveys and Questionnaires Humans Female Physical Examination Brazil |
| Zdroj: | Diabetes care. 30(2) |
| ISSN: | 0149-5992 |
| Popis: | The purpose of this study was to evaluate the effect of the single nucleotide polymorphism (SNP) -634GC at the 5' regulatory region of the vascular endothelial growth factor (VEGF) in the risk of proliferative diabetic retinopathy (PDR) in the Brazilian population of European ancestry with type 2 diabetes.A case-control study was conducted in 501 type 2 diabetic patients of European ancestry. Patients underwent a standardized clinical, ophthalmological, and laboratory evaluation. Of these, 167 patients had PDR (case patients), and 334 were considered as control subjects (patients without PDR) for PDR. A reference population (110 individuals of European ancestry) was also evaluated.No evidence of association between -634GC/VEGF and the presence of diabetic retinopathy or type 2 diabetes was observed (P0.05). However, CC homozygous for the SNP -634GC was significantly more frequent in patients with PDR (37 of 167; 22.2%) than in the corresponding control group (40 of 334; 12%) in accordance with a recessive model (P = 0.003). This effect was further observed when creatinine, BMI, sex, duration of type 2 diabetes, HDL cholesterol, and systolic blood pressure were taken into account (odds ratio 1.9 [95% CI 1.01-3.79], P = 0.04).The presence of the allele -634C/VEGF in homozygosity is an independent risk factor for the development of PDR in type 2 diabetic patients of European ancestry. |
| Databáze: | OpenAIRE |
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