| Autor: |
Iwona E, Głowacka, Katarzyna, Gawron, Dorota G, Piotrowska, Mirthe, Graus, Graciela, Andrei, Dominique, Schols, Robert, Snoeck, Anita, Camps, Emiel, Vanhulle, Kurt, Vermeire |
| Rok vydání: |
2022 |
| Zdroj: |
Antiviral research. |
| ISSN: |
1872-9096 |
| Popis: |
In this study, a series of 48 hybrids of the functionalised 1-[(1H-1,2,3-triazole-4-yl)methyl]quinazoline-2,4-dione 17-22 were synthesised and evaluated for potential antiviral activity. The new hybrids were designed to contain a diethoxyphosphoryl group connected to the triazole moiety via ethylene or propylene linker, and in which the benzyl or benzoyl function is substituted at N3 in the quinazoline-2,4-dione moiety. The Cu(I)-catalyzed Hüisgen dipolar cycloaddition of azidophosphonates 23 and 24 with the respective N |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect