Black Tea Polyphenols Inhibit Tumor Proteasome Activity
| Autor: | MUJTABA, TASKEEN, DOU, Q. PING |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Models
Molecular Molecular Structure Tea Plant Extracts food and beverages Polyphenols Article Catechin Neoplasm Proteins Fungal Proteins Plant Leaves Protein Subunits Gallic Acid Yeasts Fermentation Tumor Cells Cultured Anticarcinogenic Agents Biflavonoids Humans Computer Simulation Protease Inhibitors Drug Screening Assays Antitumor Multiple Myeloma Proteasome Inhibitors Cell Division |
| Popis: | Tea is a widely consumed beverage and its constituent polyphenols have been associated with potential health benefits. Although black tea polyphenols have been reported to possess potent anticancer activities, the effect of its polyphenols, theaflavins on the tumor’s cellular proteasome function, an important biological target in cancer prevention, has not been carefully studied. Here black tea extract (T5550) enriched in theaflavins inhibited the chymotrypsin-like (CT) activity of the proteasome and proliferation of human multiple myeloma cells in a dose-dependent manner. Also an isolated theaflavin (TF-1) can bind to, and inhibit the purified 20S proteasome, accompanied by suppression of tumor cell proliferation, suggesting that the tumor proteasome is an important target whose inhibition is at least partially responsible for the anti-cancer effects of black tea. |
| Databáze: | OpenAIRE |
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