Osteoporosis: an unusual presentation of childhood Crohn's disease

Autor: M, Thearle, M, Horlick, J P, Bilezikian, J, Levy, J M, Gertner, L S, Levine, M, Harbison, W, Berdon, S E, Oberfield
Rok vydání: 2000
Předmět:
Zdroj: The Journal of clinical endocrinology and metabolism. 85(6)
ISSN: 0021-972X
Popis: Osteoporosis is known to be associated with Crohn's disease. We report a 12-yr-old boy without a history of steroid use, in whom severe osteoporosis and multiple collapsed vertebrae were the presenting manifestations of Crohn's disease. After treatment of the Crohn's disease, he resumed normal growth and progressed through puberty. Concomitantly, he demonstrated a substantial recovery of vertebral bone mineral density and structure. Possible pathophysiological mechanisms underlying the osteoporosis and the subsequent improvement in bone density are discussed.
Databáze: OpenAIRE