[Stimulation of antigen Thy-1 expression in mouse bone marrow cells by thymus extracts]

Autor: R G, Lukashova, I A, Bezvershenko, M G, Boĭko
Rok vydání: 1983
Předmět:
Zdroj: Ukrainskii biokhimicheskii zhurnal (1. 55(1)
ISSN: 0201-8470
Popis: The expression of antigen Thy-1 was studied in bone marrow cells of CBA line mice under the effect of thymus extracts. Extracts of the calf thymus--thymosine (fraction 5) and the preparation free of the Comsa factor were obtained by a combination of the Goldstein and Comsa extraction methods. The both extracts stimulate the expression of antigen Thy-1 in bone marrow cells. Incorporation of [14 C]sodium acetate into fragments containing antigen Thy-1 and absorbed by the column with anti-Thy-1-antibodies remains unchanged after stimulation. It is supposed that antigen Thy-1 ability to stimulate expression in bone marrow precursors of T-cells is not due to the synthesis of the antigen and is a property of one of the thymus factors with molecular mass of about 5000.
Databáze: OpenAIRE