[Sensitivity of human glial tumor cells of different grade of anaplasia to lysis due to natural killers depending on some characteristics of the glycoprotein structure of tumor cell membranes]

Autor:	K I, Lisianyĭ, O V, Markova, S A, Romodanov
Rok vydání:	1991
Předmět:	Killer Cells Natural Membrane Glycoproteins Tumor Cells Cultured Humans Neuraminidase Oligosaccharides Glioma Astrocytoma
Zdroj:	Biulleten' eksperimental'noi biologii i meditsiny. 112(8)
ISSN:	0365-9615
Popis:	A study is presented of the sensitivity of freshly isolated cells (13 cases) to lysis due to natural killers (NK) depending on their malignancy grade and degree of their membrane sialization. The diagnoses were verified histologically (I-II grade gliomas-4 cases, grade III gliomas-3 cases, grade IV gliomas-6 cases). It was established that grade IV gliomas were most sensitive to NK-lysis. Treatment of tumor cells with neuraminidase increased the sensitivity to NK-lysis of grade I-III glioma cells and did not influence the sensitivity of grade IV gliomas. It is suggested that glycoprotein oligosaccharides of glial tumour cell membranes may play the role of target structures for lymphocytes-killers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f079f569a56c7639861c53265f1ce636 https://pubmed.ncbi.nlm.nih.gov/1786388 Zobrazit plný text záznamu