Foreign body granulomatosis. Clinical and immunologic findings
| Autor: | S K, Radow, I, Nachamkin, C, Morrow, R P, Fairman, M, Fratkin, G E, Rodriguez, F L, Glauser |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Male Pentazocine Substance-Related Disorders Foreign-Body Reaction Antibodies Monoclonal Gallium Radioisotopes T-Lymphocytes Helper-Inducer Peptidyl-Dipeptidase A Lymphocyte Activation T-Lymphocytes Regulatory Bronchoscopy Injections Intravenous Humans Pulmonary Diffusing Capacity Radionuclide Imaging Therapeutic Irrigation Lung Tablets |
| Zdroj: | The American review of respiratory disease. 127(5) |
| ISSN: | 0003-0805 |
| Popis: | We studied the clinical and immunologic features of 10 patients with foreign body granulomatosis associated with injection of pentazocine. Five had typical micronodules on chest radiographs, 9 had abnormal 67Ga lung images, and 9 had elevated serum angiotensin-converting enzyme levels. Pulmonary function tests showed significant decreases in diffusing capacity in 8 subjects, but were otherwise normal. Bronchoalveolar lavage fluid had significantly (p less than 0.02) increased total cell numbers (13.8 +/- 7.5 x 10(7) and significantly lower percentages of lymphocytes (2 +/- 1) and neutrophils (2 +/- 1) (p less than 0.02) when compared with that from control subjects. Peripheral blood lymphocytes were normal when expressed as percentages of total leukocytes or as percent T-lymphocytes. Monoclonal antibody determinations of T-lymphocyte subsets (helper and suppressor) were similar to those in control subjects (p = NS). Lymphocyte transformation responses to a variety of antigens and skin test reactivity were normal. Foreign body granulomatosis contrasts with other interstitial lung diseases in its bronchoalveolar lavage cellular profile and in the absence of altered peripheral immunologic indexes. |
| Databáze: | OpenAIRE |
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