Aedes aegypti anti-salivary gland antibody concentration and dengue virus exposure history in healthy individuals living in an endemic area in Colombia
| Autor: | Berlín, Londoño-Rentería, Jenny C, Cárdenas, Jennifer E, Giovanni, Lucio, Cárdenas, Paloma, Villamizar, Jennifer, Rolón, Daniel M, Chisenhall, Rebecca C, Christofferson, Daisy J, Carvajal, Omar G, Pérez, Dawn M, Wesson, Christopher N, Mores |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Adolescent Endemic Diseases Enzyme-Linked Immunosorbent Assay Pilot Projects Colombia Antibodies Viral Dengue Young Adult Aedes Water Supply Surveys and Questionnaires Animals Humans Salivary Proteins and Peptides Child Aged Environmental Exposure Dengue Virus Middle Aged Insect Vectors Socioeconomic Factors Child Preschool Immunoglobulin G Larva Housing Insect Proteins Female |
| Zdroj: | Biomedica : revista del Instituto Nacional de Salud. 35(4) |
| ISSN: | 2590-7379 |
| Popis: | Mosquito salivary proteins are able to induce an antibody response that reflects the level of human-vector contact. IgG antibodies against dengue virus (DENV-IgG) are indicators of previous exposure. The risk of DENV transmission is not only associated to mosquito or dengue factors, but also to socioeconomic factors that may play an important role in the disease epidemiology.To determine the effect of the presence of Aedes aegypti mosquitos in different stages in households and the history of dengue exposure on vector-human contact determined by the level of anti-salivary protein antibodies in people living in a Colombian endemic area.A pilot study of 58 households and 55 human subjects was conducted in Norte de Santander, Colombia. A questionnaire for socioeconomic factors was administered and houses were examined for the presence of Ae. aegypti specimens in the aquatic stages. The level of DENV-IgG antibodies (DENV-IgG), in addition to IgG and IgM anti- Ae. aegypti salivary gland extract (SGE) antibodies (SGE-IgG, SGE-IgM) were evaluated by ELISA using blood collected in filter paper.We found a significant higher level of SGE-IgG antibodies in subjects living in houses with Ae. aegypti in aquatic stages. We also found a higher concentration of SGE-IgG antibodies in people exposed to DENV, a positive correlation between IgM-SGE and IgG-DENV and a negative correlation with IgG-SGE.Anti-salivary proteins antibodies are consistent with the presence of Ae. aegypti aquatic stages inside houses and DENV-IgG antibodies concentrations. |
| Databáze: | OpenAIRE |
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