| Autor: |
R H, Gelber, P, Siu, M, Tsang, V, Richard, S K, Chehl, L P, Murray |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association. 63(2) |
| ISSN: |
0148-916X |
| Popis: |
In these studies we evaluated the activity of low levels of five antimicrobials against Mycobacterium leprae-infected mice when administered singly and in all possible two- and three-drug combinations. Antibiotics studied were: dapsone (D) 0.0001% in the diet, rifampin (R) 20 mg/kg by gavage once monthly, minocycline (M) 0.004% in the diet, clarithromycin (C) 0.001% in the diet, and sparfloxacin (S) 5 mg/kg by gavage five times weekly. Singly each agent was found bacteriostatic (D + R) or partially bactericidal (M, C, and S) but not fully bactericidal. All 10 two-drug regimens were found at least bacteriostatic, 2 being "partially bactericidal" and 4 being "fully bactericidal." Of the 10 three-drug regimens, 9 were found "fully bactericidal" and the other "partially bactericidal." We conclude that combinations of antibiotics active against M. leprae are generally additive in combination. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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