| Autor: |
M M, Maxwell, J, Nearing, N, Aziz |
| Rok vydání: |
1995 |
| Předmět: |
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| Zdroj: |
The Journal of biological chemistry. 270(42) |
| ISSN: |
0021-9258 |
| Popis: |
Ke 6 gene is a newly identified gene located in the major histocompatibility complex and is a candidate steroid dehydrogenase gene because of structural homology and regulatory similarities with mammalian steroid dehydrogenases. We report here the complete nucleotide sequence and intron-exon organization of the Ke 6 gene and cloning of the alternatively spliced Ke 6b transcript. We find that Ke 6 gene expression is down-regulated in pcy mice which is a murine model of polycystic kidney disease (PKD). Thus far, Ke 6 gene expression is down-regulated in all murine models of PKD we have examined. Abnormal steroid metabolism as a possible cause of PKD is discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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