Progression of obsessive compulsive disorder-like grooming in Sapap3 knockout mice: A longitudinal [

Autor:	Dorien, Glorie, Jeroen, Verhaeghe, Alan, Miranda, Istvan, Kertesz, Leonie, Wyffels, Sigrid, Stroobants, Steven, Staelens
Rok vydání:	2019
Předmět:	Mice Knockout Obsessive-Compulsive Disorder Pyridines Nerve Tissue Proteins Grooming Mice Inbred C57BL Mice Positron-Emission Tomography Oximes Disease Progression Animals Female Carbon Radioisotopes Longitudinal Studies
Zdroj:	Neuropharmacology. 177
ISSN:	1873-7064
Popis:	We aimed to evaluate [3-(6-methyl-pyridin-2-ylethynyl)-cyclohex-2-enone-0-Alongside the assessment of grooming, we performed [Cross-sectional comparisons revealed significantly increased grooming parameters in ko animals, at both time points. A significant longitudinal increase in % grooming duration (+268.25%; p0.05) reflected aggravation of this behavior in ko mice. [Sapap3 ko mice show a decline in mGluR5 availability in OCD relevant brain regions parallel to the worsening of OCD-like behavior. This demonstrates a potential role for [
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::eff201d0b30f8fb53d53d01fc56bdef9 https://pubmed.ncbi.nlm.nih.gov/32454126 Zobrazit plný text záznamu Full Text from ScienceDirect