| Autor: |
S L, Levy, W M, Burnham, A, Bishai, P A, Hwang |
| Rok vydání: |
1992 |
| Předmět: |
|
| Zdroj: |
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. 19(2) |
| ISSN: |
0317-1671 |
| Popis: |
Vitamin E (d-alpha-tocopherol) has proven to be a useful adjunct to anticonvulsant drugs in clinical studies. Improvement has occurred even in patients with complex partial seizures, which are often resistant to drug therapy. In animals, vitamin E is effective against ferrous chloride seizures, hyperbaric oxygen seizures and penicillin-induced seizures. It has failed, however, to show anticonvulsant effects in the standard animal models used for drug screening--the maximal electroshock and threshold pentylenetetrazol tests. The present experiments were designed to further explore the anti-epileptic actions of vitamin E in animals. Three models related to complex partial epilepsy were used: 1) the development of amygdala-kindled seizures; 2) the development of electrically-induced status in kindled animals; and 3) the development of kainic-acid seizures. Vitamin E failed to produce significant effects in any of the models. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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