[Effect of a number of antitumor preparations on RNA- and protein-synthesizing processes and viral interferon induction in Krebs 2 ascites carcinoma cells]

Autor:	D V, Shloma, T I, Krispin, I G, Balandin
Rok vydání:	1982
Předmět:	Cell-Free System Drug Evaluation Preclinical Newcastle disease virus Antineoplastic Agents In Vitro Techniques Neoplasm Proteins Carcinoma Krebs 2 Mice L Cells Animals Interferons RNA Neoplasm Encephalomyocarditis virus Cells Cultured
Zdroj:	Voprosy virusologii. 27(6)
ISSN:	0507-4088
Popis:	Antitumor drugs: adenosine cyclophosphane, adenosine thiophosphamide, colchamine thiophosphamide, and tribetamide inhibited RNA biosynthesis in Krebs-II ascitic carcinoma cells and in similar concentrations they were much less inhibiting for protein-synthesizing processes (in cells and cell-free protein-synthesizing system). The drugs could inhibit interferon synthesis, possibly after virus induction, in Krebs-II ascitic carcinoma cells only in concentrations significantly inhibiting the synthesis of cellular macromolecules.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::efa1c14d73f56a970c5f1eb20d943a22 https://pubmed.ncbi.nlm.nih.gov/6186093 Zobrazit plný text záznamu