Characterization of a pan-lymphocyte monoclonal antibody useful in differentiating leukemic from normal myeloid progenitors and monocytes from macrophages

Autor:	J S, Nadkarni, V S, Chitnis, G T, Panse, S G, Rao, J J, Nadkarni
Rok vydání:	1994
Předmět:	Mice Inbred BALB C Leukemia Leukemia Experimental Macrophages Stem Cells Antibodies Monoclonal Enzyme-Linked Immunosorbent Assay Precipitin Tests Monocytes Immunoenzyme Techniques Epitopes Mice Antigens CD Antigens Neoplasm Neoplastic Stem Cells Animals Lymphocytes
Zdroj:	Neoplasma. 41(6)
ISSN:	0028-2685
Popis:	A monoclonal antibody (McAb) designated 3A2 that recognizes a 51 kDa epitope having surface density of 37 x 10(8) per MOLT-4 cells is described. This epitope appears to be expressed on (i) lymphocytes at all stages of differentiation; (ii) leukemic myeloid progenitors; (iii) peripheral blood monocytes (MO). The epitope is specifically absent from normal myeloid progenitors and macrophages. The McAb may, therefore, be useful in studying myeloid lineage leukemias and, as a marker for monocyte to macrophage (MO + MAC) differentiation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ef889d9be4c500fba01fbe1fb6e135bd https://pubmed.ncbi.nlm.nih.gov/7532792 Zobrazit plný text záznamu