| Autor: |
Toshiro, Matsui, Sumi, Ebuchi, Tomoko, Fujise, Kanthi J M, Abesundara, Shima, Doi, Hideo, Yamada, Kiyoshi, Matsumoto |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
Biologicalpharmaceutical bulletin. 27(11) |
| ISSN: |
0918-6158 |
| Popis: |
To clarify the suppression of postprandial blood glucose rise via alpha-glucosidase (AGH) inhibitory action by natural compounds, propolis was examined in this study. A single oral administration of propolis extract (50% methanol fraction on XAD-2 column chromatography) in Sprague-Dawley rats demonstrated a potent antihyperglycemic effect with the significant AUC(0-120 min) reduction of 38% at a dose of 20 mg/kg compared to that of controls. Among the active compounds isolated from the fraction, 3,4,5-tri-caffeoylquinic acid was found to be a prominent candidate that exerts the effect and shows a strong maltase-specific inhibition with an IC(50) value of 24 microM. In addition, the noncompetitive inhibition power apparently increased with the number of caffeoyl groups bound to quinic acid. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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