| Autor: |
H, Goldschmidt, F W, Cremer, T M, Möhler, A D, Ho |
| Jazyk: |
němčina |
| Rok vydání: |
2003 |
| Předmět: |
|
| Zdroj: |
Der Internist. 44(5) |
| ISSN: |
0020-9554 |
| Popis: |
Multiple myeloma is one of the 20 most frequent malignancies in Germany. Initial symptoms are usually non-specific. Assessment of bone marrow and laboratory data as well as imaging techniques are essential for diagnosis and prognostic evaluation. Data from molecular cytogenetics have led to a better understanding of the pathogenesis of multiple myeloma. Cytostatic therapy with alcylating agents and glucocorticoids prolongs the survival. High-dose therapy followed by transplantation of autologous hematopoietic stem cells improves prognosis for patients up to the age of 70. Currently, modifications of allogeneic hematopoietic stem cell transplantation, anti-angiogeneic and immunomodulatory drugs as well as proteasome inhibitors are evaluated in clinical trials. Supportive care has derived benefit from the introduction of new bisphosphonates. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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