Disrupting the CD95-PLCγ1 interaction prevents Th17-driven inflammation

Autor:	Amanda, Poissonnier, Jean-Philippe, Guégan, Ha Thanh, Nguyen, Daniel, Best, Nicolas, Levoin, Guennadi, Kozlov, Kalle, Gehring, Raphael, Pineau, Florence, Jouan, Lucie, Morere, Sophie, Martin, Mélissa, Thomas, Estibaliz, Lazaro, Isabelle, Douchet, Thomas, Ducret, Pierre, van de Weghe, Patrick, Blanco, Mickael, Jean, Pierre, Vacher, Patrick, Legembre
Rok vydání:	2018
Předmět:	Inflammation Male Ritonavir Phospholipase C gamma Anti-Inflammatory Agents Non-Steroidal Drug Evaluation Preclinical Mice Mutant Strains Molecular Docking Simulation Disease Models Animal Structure-Activity Relationship Thiazoles Protein Domains Animals Humans Lupus Erythematosus Systemic Th17 Cells Female Peptidomimetics fas Receptor
Zdroj:	Nature chemical biology. 14(12)
ISSN:	1552-4469
Popis:	CD95L is a transmembrane ligand (m-CD95L) that is cleaved by metalloproteases to release a soluble ligand (s-CD95L). Unlike m-CD95L, interaction between s-CD95L and CD95 fails to recruit caspase-8 and FADD to trigger apoptosis and instead induces a Ca
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::eebdf5163da35e83a253a0e04a2894e9 https://pubmed.ncbi.nlm.nih.gov/30429604 Zobrazit plný text záznamu Full text from SpringerLink