| Autor: |
Yu-Dong, Dai, Qi-Jun, Sun, Bo, Meng, Shu-Liang, Xu |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
Zhongguo shi yan xue ye xue za zhi. 13(2) |
| ISSN: |
1009-2137 |
| Popis: |
To explore influence of platelet donation on donor's megakaryocytopoiesis, platelet counts and plasma concentrations of thrombopoietin (TPO), interleukin-3 (IL-3), IL-6 and nitric oxide (NO) were determined in 42 frequent platelet donors (undergoing plateletpheresis more than once a month for 24 months and their mean platelet yield of collection was 2.5 x 10(11)), in 62 limited platelet donors (undergoing plateletpheresis less than once a month for 24 months) after a donation-free period of5 weeks and in 40 whole blood donors who never undergoing plateletpheresis after a donation-free period of6 months. The results showed that the TPO levels was significantly lower in frequent platelet donors than in limited platelet donors (P0.01) and whole blood donors (P0.01). There were no significant differences between three groups in platelet counts, IL-3, IL-6 and NO. These findings suggest that the number of megakarocytes significantly increased in frequent platelet donors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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