| Autor: |
G, Squarzoni, L, Bariani, M, Ughi, R, Squerzanti, M C, Bariani, C, Fersini, G, Castaldi |
| Rok vydání: |
1990 |
| Předmět: |
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| Zdroj: |
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques. 12(4-5) |
| ISSN: |
0392-291X |
| Popis: |
Red cell carbonic anhydrase isoenzymes I and II have been measured by means of cellulose acetate membrane electrophoresis in patients with chronic renal failure and dependent on periodic hemodialysis; these patients showed a chronic anemia due to many factors. Carbonic anhydrase isoenzymes were higher in uremic and anemic patients than in the controls. Since hemoglobin can act as a protons acceptor from the active site of carbonic anhydrase during the hydratation of CO2 (and vice-versa), the increase of carbonic anhydrase can facilitate, via the Bohr effect, the transfer of the oxygen to the peripheral tissues. Therefore an increase of red cell carbonic anhydrase can constitute a compensating mechanism of anemic hypoxia in uremic patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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