| Autor: |
Zilu, Zhang, Chenjing, Ye, Jia, Liu, Wenbin, Xu, Chao, Wu, Qing, Yu, Xiaoguang, Xu, Xinyi, Zeng, Huizi, Jin, Yingli, Wu, Hua, Yan |
| Rok vydání: |
2021 |
| Zdroj: |
Cancer biologymedicine. |
| ISSN: |
2095-3941 |
| Popis: |
Multiple myeloma (MM) remains incurable with high rates of relapse. New therapeutic drugs are therefore urgently needed to improve the prognosis. JaponiconeA (JA), a natural product isolated fromCCK8 assays and flow cytometry were used to detect the proliferation, apoptosis, and cell cycle of MM cell lines when treated with JA.JA exhibited strong anti-tumor effects in MM. It sensitized myeloma cells to bortezomib and overcame NF-κB-induced drug resistance by inhibiting IKKβ, providing a new treatment strategy for MM patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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