Allergen-specific immunotherapy enhances CD8
| Autor: | Yi-Giien, Tsai, Kuender D, Yang, Yung-Sung, Wen, Chih-Hsing, Hung, Jien-Wen, Chien, Ching-Yuang, Lin |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Adolescent CD8 Antigens Dermatophagoides pteronyssinus Interleukin-2 Receptor alpha Subunit Forkhead Transcription Factors Nitric Oxide T-Lymphocytes Regulatory Toll-Like Receptor 2 Lipopeptides Tumor Necrosis Factor Receptor Superfamily Member 9 Adjuvants Immunologic Desensitization Immunologic Hypersensitivity Animals Humans Female Antigens Dermatophagoides RNA Small Interfering Child Cells Cultured Cell Proliferation |
| Zdroj: | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 30(5) |
| ISSN: | 1399-3038 |
| Popis: | 4-1BB (CD137), a member of the inducible tumor necrosis factor receptor (TNFR) family, is expressed on regulatory T (Treg) cells and regulates Treg cells to control allergic inflammation. Pam3CSK4, a synthetic TLR2 ligand that can expand CD8Nasal symptom scores, nNO levels, PBMCs, and inferior turbinate biopsies were obtained from 40 mite-sensitive perennial allergic rhinitis (PAR) patients before and after one year of Der p IT and 30 non-allergic control subjects. CD137 expression on CD8Der p IT improved nasal symptom scores, decreased nNO levels, and increased CD137 expression on CD8Der p IT expanded CD8 |
| Databáze: | OpenAIRE |
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