Pharmacokinetics, safety, tolerability and efficacy of cotadutide, a glucagon-like peptide-1 and glucagon receptor dual agonist, in phase 1 and 2 trials in overweight or obese participants of Asian descent with or without type 2 diabetes

Autor:	Michiko, Asano, Akiko, Sekikawa, Hyosung, Kim, Robert A, Gasser, Darren, Robertson, Marcella, Petrone, Lutz, Jermutus, Philip, Ambery
Rok vydání:	2021
Předmět:	Adult Diabetes Mellitus Type 2 Double-Blind Method Glucagon-Like Peptide 1 Glucagon-Like Peptides Receptors Glucagon Humans Hypoglycemic Agents Obesity Overweight Glucagon Peptides Glucagon-Like Peptide-1 Receptor
Zdroj:	Diabetes, obesitymetabolismREFERENCES. 23(8)
ISSN:	1463-1326
Popis:	To evaluate the safety and pharmacokinetics of cotadutide, a dual glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist, in overweight Asian participants with or without type 2 diabetes (T2D).In the phase 1, randomized, blinded, single-ascending dose study, 24 Japanese and eight Chinese healthy adults (body mass index [BMI] 23-40 kg/mSignificant reductions from baseline to day 48 were observed with cotadutide for glucose AUCOnce-daily cotadutide was effective and well tolerated up to 300 μg in overweight Japanese patients with T2D. Further evaluation in Asian populations is warranted.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ee4de216eafd66b3654f0669a45f0d5f https://pubmed.ncbi.nlm.nih.gov/33908687 Zobrazit plný text záznamu Plný text