Ultrastructural and biosynthetic characteristics of epidermal cells in patients with psoriasis treated with antiproliferative drugs

Autor:	Y M, Krinitsyna, G I, Nepomnyashchikh, S V, Aidagulova
Rok vydání:	2001
Předmět:	Methotrexate Photochemotherapy Biopsy Etretinate Intermediate Filaments Humans Psoriasis RNA DNA Epidermis Cell Division Growth Inhibitors
Zdroj:	Bulletin of experimental biology and medicine. 132(2)
ISSN:	0007-4888
Popis:	Biopsy specimens from patients with psoriasis treated with antiproliferative drugs (methotrexate, etretinate) were analyzed. Acanthosis and papillomatosis of the epidermis and inflammatory reaction of the derma decreased. A tendency to normalization of epidermocyte ultrastructure with regeneration of tonofilaments and normal keratinization was noted. An important role in the morphogenesis of this process belongs to interrelationships of two competitive types of biosynthesis, DNA and RNA synthesis, providing epidermocyte proliferation and intracellular regeneration, respectively. Structural and functional composition optimal for the epidermis is formed under conditions of complex treatment with antiproliferative drugs combined with photochemotherapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ee4b78243521c5d6b408b1ebcc1f7047 https://pubmed.ncbi.nlm.nih.gov/11713570 Zobrazit plný text záznamu Full text from SpringerLink