| Autor: |
Juliana Moreira de Almeida, Sant'ana, Roger, Chammas, Fu-Tong, Liu, Suely, Nonogaki, Sérgio Vitorino, Cardoso, Adriano Mota, Loyola, Paulo Rogério, de Faria |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Anticancer research. 31(9) |
| ISSN: |
1791-7530 |
| Popis: |
Galectin-3 has been associated with activated Wnt pathway, translocating beta-catenin into the nucleus. However, it is still unknown whether this lectin drives the Wnt signaling activation in lesions from galectin-3-deficient (Gal3⁻/⁻) mice. The purpose was to study beta-catenin expression in tongue lesions from Gal3⁻/⁻ and wild-type (Gal3⁺/⁺) mice and the status of Wnt signaling.Twenty Gal3⁻/⁻ and Gal3⁺/⁺ male mice were challenged with 4-nitroquinolin-1-oxide and killed at week 16 and 32. Tongues were processed and stained with HE to detect dysplasias and carcinomas. An imunohistochemical assay was performed to evaluate beta-catenin expression.Carcinomas were more evident in Gal3⁺/⁺ than Gal3⁻/⁻ mice (55.5% vs. 28.5%, respectively; p0.05). Elevated expression of non-membranous beta-catenin was observed in dysplasias and carcinomas from both groups (p0.05).Absence of galectin-3 does not interfere in the pattern of beta-catenin expression and therefore in the mediation of the Wnt signaling pathway. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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