Role of the thymus in radiation-induced lung damage after bone marrow transplantation
| Autor: | W H, McBride, V, Vegesna |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Mice
Inbred C3H Time Factors Dose-Response Relationship Radiation Thymus Gland Thymectomy Survival Rate Graft vs Host Reaction Mice Radiation Injuries Experimental Transplantation Isogeneic Lymphocyte Transfusion Animals Regeneration Female Lung Spleen Whole-Body Irradiation Bone Marrow Transplantation |
| Zdroj: | Radiation research. 147(4) |
| ISSN: | 0033-7587 |
| Popis: | Pneumonitis developing after total-body irradiation and bone marrow transplantation can be a serious complication of this form of therapy. In this study, the incidence of lung damage in a murine syngeneic transplant model was found to be decreased by prior removal of the thymus, indicating that thymus-derived cells, even in the absence of complicating factors such as graft-versus-host disease and opportunistic pathogens, can contribute to radiation-induced lung damage. It is suggested that the increased damage is due to a syngeneic graft-versus-host reaction mediated by a regenerating lymphoid system. If this concept is correct, new strategies can be identified that might be employed in altering the incidence of this serious transplant-related complication. |
| Databáze: | OpenAIRE |
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