[Coronary angioplasty in the real world: the RESTEM registry. Outcome of patients treated with sirolimus-eluting stents]
| Autor: | Luigi, Campolo, Paolo, Pantaleo, Maria Cristina, Barattoni, Arianna, Berardo, Luca, Ghetti, Danilo, Fusco, A, Maggioni |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Sirolimus Time Factors Myocardial Infarction Coronary Disease Drug-Eluting Stents Coronary Angiography Coronary Restenosis Treatment Outcome Data Interpretation Statistical Multivariate Analysis Humans Multicenter Studies as Topic Female Prospective Studies Registries Angioplasty Balloon Coronary Coronary Artery Bypass Immunosuppressive Agents Follow-Up Studies |
| Zdroj: | Giornale italiano di cardiologia (2006). 9(4) |
| ISSN: | 1827-6806 |
| Popis: | RESTEM, a prospective multicenter registry collecting all percutaneous coronary interventions made over 20 months and monitored up to 2 years, had been performed to assess, in the real world, the impact of sirolimus-eluting stents (SES) versus bare metal stents (BMS) on patients' outcomes.The registry includes 5524 consecutive patients treated with BMS (72%), SES (15%), BMS+SES (4%) or other techniques (9%). The combination of death, acute myocardial infarction, unstable angina and revascularization had been chosen as primary endpoint.The 2-year adjusted results confirm a significant advantage of SES in target vessel revascularization (8.3 vs 13.7%, odds ratio [OR] 0.66), a benefit for overall revascularizations (18.3 vs 25.6%, OR 0.76) without reducing mortality, other clinical events and primary endpoint, therefore denying the benefit on primary endpoint observed at 12 months (18.5 vs 25.0%, OR 0.68 at 1 year and 25.8 vs 32.4%, OR 0.84 at 2 years).RESTEM results confirm the SES capacity to reduce target vessel revascularization without decreasing other clinical events, suggest that this advantage is limited to the first 6 months after percutaneous coronary intervention, and show no evidence of excess of deaths, acute myocardial infarction and late thrombosis following SES implantation described in recent meta-analyses. |
| Databáze: | OpenAIRE |
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