Effects of netropsin and pentamidine amino analogues on the amidolytic activity of plasmin, trypsin and urokinase

Autor:	Anna, Pućkowska, Krystyna, Midura-Nowaczek, Irena, Bruzgo
Rok vydání:	2008
Předmět:	Structure-Activity Relationship Netropsin Fibrinolysin Amines Trypsin Inhibitors Urokinase-Type Plasminogen Activator Pentamidine
Zdroj:	Acta poloniae pharmaceutica. 65(2)
ISSN:	0001-6837
Popis:	Inhibitory effects of nine carbocyclic DNA minor groove binders on amidolytic activities of plasmin, trypsin and urokinase were examined. Some of the studied compounds affected plasmin or trypsin activity, but not urokinase activity. One of the pentamidine analogues (5) and two bis-netropsin like compounds (6, 8) were potent inhibitors of plasmin (IC50 equals 90 and 100 microM), whereas an analogue of netropsin (2) was trypsin inhibitor (IC50 = 100 microM).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ee226e1991f653f1562a85201773c577 https://pubmed.ncbi.nlm.nih.gov/18666427 Zobrazit plný text záznamu