Non-islet cell tumor hypoglycemia caused by a big insulin-like growth factor II- producing hepatocellular carcinoma:an autopsy case report

Autor: Hirohito, Naruse, Norihiko, Shimoyama, Tsugumi, Satoh, Yoshiya, Yamamoto, Kazuteru, Hatanaka, Taiki, Kudo, Masayoshi, Ohno, Kazuharu, Suzuki, Hajime, Hirata, Marina, Suzuki
Rok vydání: 2016
Předmět:
Zdroj: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology. 113(12)
ISSN: 0446-6586
Popis: A 73-year-old man with a hepatocellular carcinoma was admitted to our hospital. He suffered from recurrent severe hypoglycemia. An autopsy was performed after his death. Anti-insulin-like growth factor II (IGF-II) monoclonal antibody immunostaining of the hepatocellular carcinoma was positive. Western immunoblot analysis of the serum revealed highly elevated IGF-II. Therefore, we diagnosed this case as a non-islet cell tumor hypoglycemia caused by a big IGF-II-producing hepatocellular carcinoma.
Databáze: OpenAIRE