| Autor: |
Toshikazu, Moriwaki, Ichinosuke, Hyodo, Tomohiro, Nishina, Takeshi, Kajiwara, Junro, Kataoka, Shinichiro, Hori, Junichirou, Nasu, Satoshi, Imamine, Haruo, Iguchi |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
Gan to kagaku ryoho. Cancerchemotherapy. 34(13) |
| ISSN: |
0385-0684 |
| Popis: |
The clinical efficacy and safety of irinotecan plus infusional fluorouracil/l-leucovorin (FOLFIRI) in patients with fluoropyrimidine-resistant metastatic colorectal cancer were studied retrospectively. 20 patients were treated with FOLFIRI at our hospital between October 2003 and November 2005. The objective overall response rate was 28% (5/18; 95% confidence interval, 9.7-54%). The disease control rate (CR+PR+SD) was 61%. The most frequent grade 3 to 4 adverse event was neutropenia, and it was seen in 50%. Non-hematological toxicities were mild. The median survival time was 11 months. The 1-year survival rate was 34%. This study showed the activity and safety of FOLFIRI in practice. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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