| Autor: |
Ann-Kathrin, Rahm, Teresa, Wieder, Dominik, Gramlich, Mara Elena, Müller, Maximilian N, Wunsch, Fadwa A, El Tahry, Tanja, Heimberger, Tanja, Weis, Patrick, Most, Hugo A, Katus, Dierk, Thomas, Patrick, Lugenbiel |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Life sciences. 266 |
| ISSN: |
1879-0631 |
| Popis: |
Atrial fibrillation (AF) with concomitant heart failure (HF) is associated with prolonged atrial refractoriness. Small-conductance, calcium-activated KHDAC2 and KCNN2/3 transcript levels were quantified in patients with AF and HF, and in a porcine model of atrial tachypacing-induced AF and reduced left ventricular function. Tachypacing and anti-Hdac2 siRNA treatment were employed in HL-1 atrial myocytes to study effects on KCNN2/3 mRNA and KAtrial KCNN2 and KCNN3 expression was reduced in AF/HF patients and in a corresponding pig model. HDAC2 displayed significant downregulation in humans and a tendency towards reduced expression in right atrial tissue of pigs. Tachypacing recapitulated downregulation of Kcnn2/KKCNN2/3 and HDAC2 expression is suppressed in AF complicated by HF. Hdac2 directly regulates Kcnn3 mRNA levels in atrial cells. The mechanistic and therapeutic significance of epigenetic electrophysiological effects in AF requires further validation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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